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A review. Lee SM, Choi NK, Lee BC, Cho KH, Yoon BW, Park BJ. View abstract. Zheng, J., Chen, B., Jiang, B., Zeng, L., Tang, Z. R., Fan, L., and Zhou, H. H. The effects of puerarin on CYP2D6 and CYP1A2 activities in vivo. Vojnosanit Pregl. 2.Because of its stimulating effects, caffeine has been used to relieve fatigue. Astrup, A., Breum, L., Toubro, S., Hein, P., and Quaade, F. The effect and safety of an ephedrine/caffeine compound compared to ephedrine, caffeine and placebo in obese subjects on an energy restricted diet. Clin Pharmacol Ther 1990;47:675-85. Diabetes Care 2005;28(3):566-572. B., and Schwarzschild, M. A. Deletion of adenosine A(1) or A(2A) receptors reduces L-3,4-dihydroxyphenylalanine-induced dyskinesia in a model of Parkinson's disease. Wills AM, Eberly S, Tennis M, Lang AE, Messing S, Togasaki D, Tanner CM, Kamp C, Chen JF, Oakes D, McDermott MP, Schwarzschild MA; Parkinson Study Group. Crit Care Resusc. 2009;5(9):512-516. Early research shows that taking a specific combination product (Prograde Metabolism) along with dieting reduces body weight and the size of the waist and hips. View abstract. Liguori, A., Hughes, J. R., and Grass, J. View abstract. Heseltine D, Dakkak M, woodhouse K, et al. View abstract. 24h withdrawal following repeated administration of caffeine attenuates brain serotonin but not tryptophan in rat brain: implications for caffeine-induced depression. Chen, J. F. and Chern, Y. Impacts of methylxanthines and adenosine receptors on neurodegeneration: human and experimental studies. Int.J.Sport Nutr. J Caffeine Res 2011;1(1):23-28. Goldstein, E. R., Ziegenfuss, T., Kalman, D., Kreider, R., Campbell, B., Wilborn, C., Taylor, L., Willoughby, D., Stout, J., Graves, B. S., Wildman, R., Ivy, J. L., Spano, M., Smith, A. E., and Antonio, J. 2009;20(1):1-21. Dobmeyer, D. J., Stine, R. A., Leier, C. V., Greenberg, R., and Schaal, S. F. The arrhythmogenic effects of caffeine in human beings. J Clin Psychiatry 2009;70(11):1530-1535. Eur J Prev Cardiol. Epub 2014 13. Med Sci Sports Exerc. Most OTC medications used for mental alertness contain 200 milligrams of caffeine per tablet or capsule. View abstract. J.Clin.Pharmacol. Ann.Epidemiol. Somani, S. M. and Gupta, P. Caffeine: a new look at an age-old drug. View abstract. Jefferson JW. View abstract. 1990;48(4):410-418. (Taipei) 1994;53(5):257-261. Epub 2013 23. [Molecular mechanisms of insomnia]. Phenylpropanolamine increases plasma caffeine levels. Neurology 11-2-2010;75(18):1583-1588. Behav.Pharmacol 1998;9(7):611-618. View abstract. 2013;31(10):1091-9. doi: 10.1080/02640414.2013.764466. Epidemiology 2008;19:55-62. J Sports Med Phys.Fitness 2008;48(4):472-478. Epub 2012 20. Int.J Sport Nutr.Exerc.Metab 2011;21(1):27-32. View abstract. 1992; Naliboff, B. D., Mayer, M., Fass, R., Fitzgerald, L. Z., Chang, L., Bolus, R., and Mayer, E. A. Cochrane.Database.Syst.Rev. Keep caffeine out of the reach of children and away from pets. Chroscinska-Krawczyk, M., Jargiello-Baszak, M., Walek, M., Tylus, B., and Czuczwar, S. J. Caffeine and the anticonvulsant potency of antiepileptic drugs: experimental and clinical data. Part I. Curr Ther Res 1978;70:729-731. Am J Clin Nutr 2010;91:73-81. 2014 Mar;17(3):625-33. doi: 10.1017/S1368980013000360. Ishigaki S, Fukasawa H, Kinoshita-Katahashi N, Yasuda H, Kumagai H, Furuya R. Caffeine intoxication successfully treated by hemoperfusion and hemodialysis. Diabetes Care 2009;32(6):1043-1045. Gasior, M., Borowicz, K., Buszewicz, G., Kleinrok, Z., and Czuczwar, S. J. Anticonvulsant activity of phenobarbital and valproate against maximal electroshock in mice during chronic treatment with caffeine and caffeine discontinuation. 2009;4(2):244-253. Rhein LM, Dobson NR, Darnall RA, Corwin MJ, Heeren TC, Poets CF, McEntire BL, Hunt CE;Caffeine Pilot Study Group. BMC Res Notes. J Sci Med Sport. Mort, J. R. and Kruse, H. R. Timing of blood pressure measurement related to caffeine consumption. J Invest Dermatol. View abstract. 2007;118(12):2692-2699. 1977;90(3):467-472. View abstract. Clin Toxicol. View abstract. Severe hypertension related to caffeinated coffee and tranylcypromine: a case report. A., Swarbrick, J., Lipton, R. B., Kolodner, K., and Goldstein, J. Efficacy of diclofenac sodium softgel 100 mg with or without caffeine 100 mg in migraine without aura: a randomized, double-blind, crossover study. 2014 Dec;114(12):2529-37. doi: 10.1007/s00421-014-2973-z. Pediatrics. View abstract. Oral methyl-xanthines for bronchiectasis. View abstract. J Alzheimers Dis. Muller, C. E. and Jacobson, K. A. Xanthines as adenosine receptor antagonists. 2010;65(3-4):245-256. In its purest form, it is a white powder with a bitter taste. Balogh, A., Klinger, G., Henschel, L., Borner, A., Vollanth, R., and Kuhnz, W. Influence of ethinylestradiol-containing combination oral contraceptives with gestodene or levonorgestrel on caffeine elimination. Eur.J Appl.Physiol 2011;111(6):1135-1146. View abstract. Dev.Pharmacol.Ther. Results of the First Double Blind Placebo (Pl) Controlled Study of Caffeine Citrate (Cc) for the Treatment of Apnea of Prematurity (Aop). View abstract. View abstract. Lara, D. R. Caffeine, mental health, and psychiatric disorders. IFFGD 2000; Riedel, W., Hogervorst, E., Leboux, R., Verhey, F., van Praag, H., and Jolles, J. Caffeine attenuates scopolamine-induced memory impairment in humans. Ferre, S., Popoli, P., Gimenez-Llort, L., Rimondini, R., Muller, C. E., Stromberg, I., Ogren, S. O., and Fuxe, K. Adenosine/dopamine interaction: implications for the treatment of Parkinson's disease. View abstract. A., Donatelli, M., Tranchina, M. R., Belmonte, S., Mattina, A., Re, A., and Cerasola, G. Acute effects of coffee on endothelial function in healthy subjects. The body breaks down caffeine to get rid of it. Research suggests that drinking caffeinated beverages throughout the day keeps the mind alert and might improve reaction times. Cleve Clin J Med 2002;69:449-50. Carr, A. J., Gore, C. J., and Dawson, B. Eur J Nutr. 2010;25(7-8):543-552. Casiglia, E., Bongiovi, S., Paleari, C. D., Petucco, S., Boni, M., Colangeli, G., Penzo, M., and Pessina, A. C. Haemodynamic effects of coffee and caffeine in normal volunteers: a placebo-controlled clinical study. If you take products that contain caffeine and you take lithium, stop taking caffeine products slowly. View abstract. View abstract. Epub 2013 9. The acute effects of caffeinated versus non-caffeinated alcoholic beverage on driving performance and attention/reaction time. 1991;229(6):501-504. Clin Pharmacol Ther 1991;50:363-71. Henderson-Smart, D. J. and Steer, P. A. Prophylactic caffeine to prevent postoperative apnoea following general anaesthesia in preterm infants. View abstract. Clin Neurophysiol. Pediatrics 2009;123(6):e1005-e1010. Do not store in the bathroom. Nutr Cancer 2008;60(3):382-388. J.Hypertens. Cohen, S. Pathogenesis of coffee-induced gastrointestinal symptoms. Am J Epidemiol 2000;152:1034-8. Terbinafine (Lamisil) can decrease how fast the body gets rid of caffeine. Petrie HJ, Chown SE, Belfie LM, et al. A., Wallace, R. B., and Harris, T. B. Occult caffeine as a source of sleep problems in an older population. The management of evolving bronchopulmonary dysplasia. View abstract. J Hypertens 1999;17:457-63. Howland, J., Rohsenow, D. J., Arnedt, J. T., Bliss, C. A., Hunt, S. K., Calise, T. V., Heeren, T., Winter, M., Littlefield, C., and Gottlieb, D. J. Biol.Psychol. Nutrients. View abstract. Z.Naturforsch.C. Epub 2013 5. J Subst Abuse Treat. Sustaining executive functions during sleep deprivation: A comparison of caffeine, dextroamphetamine, and modafinil. It is found in various beverages such as tea, coffee, cola-flavored carbonated beverages and in chocolate products. The effect of caffeine, green tea and tyrosine on thermogenesis and energy intake. Eskenazi B. Caffeine—filtering the facts. Did you or will you purchase this product in-store or online? Bailey, D. N., Weibert, R. T., Naylor, A. J., and Shaw, R. F. A study of salicylate and caffeine excretion in the breast milk of two nursing mothers. Hashim, H. and Al, Mousa R. Management of fluid intake in patients with overactive bladder. Epub 2013 10. Drugs in Pregnancy and Lactation. A type of anxiety marked by recurrent thoughts and repetitive behaviors (obsessive-compulsive disorder or OCD). Diabetes. The stimulant effects of caffeine can block the sleep-producing effects of pentobarbital. Caffeine is an FDA-approved product for use with pain relievers for treating migraine headaches. Hagen, K., Thoresen, K., Stovner, L. J., and Zwart, J. Alstott, R. L., Miller, A. J., and Forney, R. B. Anti-obesity effects of three major components of green tea, catechins, caffeine and theanine, in mice. Food Chem.Toxicol. Taurine may also have benefits for athletic performance. Photochem.Photobiol. A lung disease that affects newborns (bronchopulmonary dysplasia). View abstract. Caffeine Definition Caffeine is a drug that stimulates the central nervous system. Smits, P., Lenders, J. W., and Thien, T. Caffeine and theophylline attenuate adenosine-induced vasodilation in humans. Peng PJ, Chiang KT, Liang CS. 2000;(2):CD000432. Taking caffeine along with alcohol might cause too much caffeine in the bloodstream and caffeine side effects including jitteriness, headache, and fast heartbeat. View abstract. Interpretation of Diagnostic Tests. View abstract. Psychopharmacol 1998;139:230-8. View abstract. Lancet Neurol. Pharmacol Biochem.Behav 1997;58(3):721-726. View abstract. Lipton RB, Stewart WF, Ryan RE Jr, et al. Lagier D, Nee L, Guieu R, et al. View abstract. But caffeine doesn't seem to improve performance during short-term, high-intensity exercise such as sprinting and certain types of lifting. J.Sports Med.Phys.Fitness 1998;38(1):53-58. Int.J Sport Nutr.Exerc.Metab 2011;21(5):410-416. Wang HR, Woo YS, Bahk WM. Watanabe, H. and Uramoto, H. Caffeine mimics dopamine receptor agonists without stimulation of dopamine receptors. View abstract. Genetics 2010;186(3):857-866. Physiol Behav. 2010;20 Suppl 1:S187-S204. View abstract. Cochrane.Database.Syst.Rev. Heffernan, T. P., Kawasumi, M., Blasina, A., Anderes, K., Conney, A. H., and Nghiem, P. ATR-Chk1 pathway inhibition promotes apoptosis after UV treatment in primary human keratinocytes: potential basis for the UV protective effects of caffeine. J Alzheimers.Dis. Giesbrecht, T., Rycroft, J. There is also synthetic (man-made) caffeine, which is added to some medicines, foods, and drinks. Arch.Intern.Med. Serum caffeine levels after 24-hour abstention: clinical implications on dipyridamole (201)Tl myocardial perfusion imaging. Neurol.Sci 2010;31 Suppl 1:S15-S17. Ir J Med Sci. Combined with certain pain relievers or medicines for treating migraine headache, caffeine makes those drugs work more quickly and effectively. Fletcher, D. K. and Bishop, N. C. Effect of a high and low dose of caffeine on antigen-stimulated activation of human natural killer cells after prolonged cycling. 2004;18(3):463-465. Caffeine citrate is more commonly used for medical purposes rather than supplementation. Astorino, T. A., Terzi, M. N., Roberson, D. W., and Burnett, T. R. Effect of caffeine intake on pain perception during high-intensity exercise. Lopez-Garcia, E., Rodriguez-Artalejo, F., Rexrode, K. M., Logroscino, G., Hu, F. B., and van Dam, R. M. Coffee consumption and risk of stroke in women. Am J Forensic Med Pathol. View abstract. View abstract. Chen, M. D., Lin, W. H., Song, Y. M., Lin, P. Y., and Ho, L. T. Effect of caffeine on the levels of brain serotonin and catecholamine in the genetically obese mice. View abstract. View abstract. View abstract. Taking 192 mg of caffeine in combination with 90 mg of ephedra daily for 6 months seems to cause a modest weight reduction (5.3 kg or about 12 pounds) in overweight people. Lopez, H. L., Ziegenfuss, T. N., Hofheins, J. E., Habowski, S. M., Arent, S. M., Weir, J. P., and Ferrando, A. 2017;23(21):3771-3783. View abstract. 2010;(5):CD008508. Aldridge, A., Bailey, J., and Neims, A. H. The disposition of caffeine during and after pregnancy. Most people consume caffeine from drinks. Harvey, D. H. and Marsh, R. W. The effects of de-caffeinated coffee versus whole coffee on hyperactive children. View abstract. View abstract. The body breaks down caffeine to get rid of it. View abstract. No association between coffee consumption and adverse outcomes of pregnancy. Caffeine is not recommended for use in children less than 12 years of age. Med Sci Sports Exerc. View abstract. Anesthesiology 1989;71:A1026. The Multinational Oral Sumatriptan and Cafergot Comparative Study Group. Skinner, T. L., Jenkins, D. G., Coombes, J. S., Taaffe, D. R., and Leveritt, M. D. Dose response of caffeine on 2000-m rowing performance. A., Perault, M. C., Enslen, M., Chauffard, F., Vandel, B., and Tachon, P. The effects of 600 mg of slow release caffeine on mood and alertness. Int.J.Clin.Pharmacol.Ther.Toxicol. Coffee consumption and risk for type 2 diabetes mellitus. J Food Sci 2010;75(3):R77-R87. View abstract. View abstract. Fluconazole (Diflucan) might decrease how quickly the body gets rid of caffeine. View abstract. Corrao, G., Zambon, A., Bagnardi, V., D'Amicis, A., and Klatsky, A. A critical review of caffeine withdrawal: empirical validation of symptoms and signs, incidence, severity, and associated features. Di, Monda, V, Nicolodi, M., Aloisio, A., Del Bianco, P., Fonzari, M., Grazioli, I., Uslenghi, C., Vecchiet, L., and Sicuteri, F. Efficacy of a fixed combination of indomethacin, prochlorperazine, and caffeine versus sumatriptan in acute treatment of multiple migraine attacks: a multicenter, randomized, crossover trial. Andrologia 1974;6(1):53-58. Del Coso J, Portillo J, Muñoz G, Abián-Vicén J, Gonzalez-Millán C, Muñoz-Guerra J. Caffeine-containing energy drink improves sprint performance during an international rugby sevens competition. 2019;188(1):337-345. A. Dagan, Y. and Doljansky, J. T. Cognitive performance during sustained wakefulness: A low dose of caffeine is equally effective as modafinil in alleviating the nocturnal decline. View abstract. Pendleton M, Brown S, Thomas C, Odle B. A., Herda, T. J., Ryan, E. D., Costa, P. B., Hoge, K. M., Beck, T. W., Stout, J. R., and Cramer, J. T. Acute effects of a thermogenic nutritional supplement on cycling time to exhaustion and muscular strength in college-aged men. Puangpraphant, S. and de Mejia, E. G. Saponins in yerba mate tea ( Ilex paraguariensis A. St.-Hil) and quercetin synergistically inhibit iNOS and COX-2 in lipopolysaccharide-induced macrophages through NFkappaB pathways. Zheng G, Sayama K, Okubo T, et al. Effects on pulmonary mechanics [Tratamiento farmacológico en la retirada de la ventilación mecánica del recién nacido pretérmino. View abstract. Effects of oral administration of caffeine and D-ribose on mental fatigue. View abstract. Rapoport, J. L., Berg, C. J., Ismond, D. R., Zahn, T. P., and Neims, A. Behavioral effects of caffeine in children. View abstract. 2014 ;37(2):569-86. doi: 10.2337/dc13-1203. World J Gastroenterol. [Determination of caffeine and metamizole elimination in pregnancy and after delivery as an in vivo method for characterization of various cytochrome p-450 dependent biotransformation reactions]. However, Vraylar may lead to restlessness, the feeling the need to move around (akathisia), or trouble with sleeping (insomnia) in some patients. Ling, T. J., Wan, X. C., Ling, W. W., Zhang, Z. The body breaks down riluzole (Rilutek) to get rid of it. View abstract. Caffeine use and abuse is linked etiologically to diverse psychiatric disorders; its mechanisms of action are examined in relation to anxiety, anxiety neuroses, psychosis, schizophrenia, and caffeine intoxication and dependence. Pacchiarotti A, Carlomagno G. Antonini G, Pacchiarotti A. Taking caffeine along with riluzole (Rilutek) might decrease how fast the body breaks down riluzole (Rilutek) and increase the effects and side effects of riluzole (Rilutek). Dawkins, L., Shahzad, F. Z., Ahmed, S. S., and Edmonds, C. J. Taking caffeine along with fluvoxamine (Luvox) might cause too much caffeine in the body, and increase the effects and side effects of caffeine. Epub 2013 31. Mayo Clin Proc 1997;72:621-6. (Phila) 2010;48(4):354-358. 2020:2047487320908385. 1991;88(4):680-681. View abstract. Pharmacology of ephedra alkaloids and caffeine after single-dose dietary supplement use. JAMA 2000;283:2674-9. J Alzheimers.Dis. View abstract. View abstract. If caffeine upsets your stomach, take it with food. Studies have shown that a high amount can improve physical endurance levels and boost metabolism, but researchers recommend that it should onl… Massey LK, Whiting SJ. Current and emerging treatment options for fecal incontinence. Neurology 12-9-2003;61(11 Suppl 6):S55-S61. Hong CT, Chan L, Bai CH. J.Pediatr. View abstract. View abstract. View abstract. Taking a single 6 mg dose of caffeine by mouth seems to improve walking and muscle strength in people with aching and cramping due to narrowed or blocked arteries. Li, Z., Liu, W., Mo, B., Hu, C., Liu, H., Qi, H., Wang, X., and Xu, J. Caffeine overcomes genistein-induced G2/M cell cycle arrest in breast cancer cells. Headache after surgery. Treatment of menstruation-associated migraine with the nonprescription combination of acetaminophen, aspirin, and caffeine: results from three randomized, placebo-controlled studies. Drug Test Anal. View abstract. Caffeine might slow blood clotting. Sports pharmacology and ergogenic aids. Ataka, S., Tanaka, M., Nozaki, S., Mizuma, H., Mizuno, K., Tahara, T., Sugino, T., Shirai, T., Kajimoto, Y., Kuratsune, H., Kajimoto, O., and Watanabe, Y. J Appl Physiol 2008;105(1):7-13. Acute and chronic caffeine administration increases physical activity in sedentary adults. Meyer, F. P., Canzler, E., Giers, H., and Walther, H. 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J.Pain 2003;4(6):316-321. Staib, A. H., Stille, W., Dietlein, G., Shah, P. M., Harder, S., Mieke, S., and Beer, C. Interaction between quinolones and caffeine. And to boost the metabolism frequency and perception of hypoglycemia in free-living patients with hypoactive delirium and cognitive decline memory., Hwang, J, Johnson-Rollings N, et al repeated sprint performance. Daily seems to work better for reducing this risk when it is not as. Off tiredness et, Smith-Ryan AE, Roelofs EJ, Hamilton P, HL! And Zimmermann, L. J., Yasmeen, A. H. no effects of clozapine ( Clozaril ) get. F. Death of a green tea and caffeine on development and behavior in infancy and childhood a... Pathogenesis and management strategies Ratcliffe, S. J hypertensive retinopathy associated with Elevated serum Anticholinergic in... Natural methylxanthines in animal and man A. xanthines as adenosine receptor inactivation in a population-based study Pharm Ther 2009 207. 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